Methylenetetrahydrofolate dehydrogenase, NAD-binding domain (IPR035812)

Short name: m-THF_DH_NAD-bd

Overlapping homologous superfamilies

Domain relationships


Methylene-tetrahydrofolate (m-THF) is a versatile carrier of activated one-carbon units. The oxidation of metabolic intermediate methylene-THF to methenyl-THF requires the enzyme methylene-tetrahydrofolate dehydrogenase (m-THF DH). In eukaryotes, m-THF DH is typically found as part of a multifunctional protein. NADP-dependent m-THF DHs in mammals, birds and yeast are components of a trifunctional enzyme with DH, cyclohydrolase, and synthetase activities. Certain eukaryotic cells also contain homodimeric bifunctional DH/cyclodrolase form. In bacteria, monofunctional DH, as well as bifunctional DH/cyclodrolase are found. In addition, yeast (S. cerevisiae) also express an monofunctional DH. This family contains only the monofunctional DHs from yeast [PMID: 10933503].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.