Phosphatidylethanolamine-binding protein, eukaryotic (IPR035810)

Short name: PEBP_euk

Overlapping homologous superfamilies

Family relationships


Phosphatidylethanolamine-binding proteins (PEBPs) are present in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1), which function as a promoter and a repressor of the floral transitions respectively [PMID: 17540570, PMID: 21890645, PMID: 16424903], as well as the mammalian Raf kinase inhibitory protein (RKIP), also known as phosphatidylethanolamine-binding protein 1 (PEBP-1), which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades [PMID: 18379591, PMID: 22610096]. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.