Domain

Pyruvate dehydrogenase E1 component, N-terminal (IPR035807)

Short name: PDC_E1_N

Overlapping homologous superfamilies

Domain relationships

None.

Description

Pyruvate dehydrogenase multienzyme complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and the subsequent acetylation of coenzyme A to acetyl-CoA. The E1 component of PDC catalyzes the first step of the multistep process, using thiamine pyrophosphate (TPP) and a divalent cation as cofactors. E. coli PDC is a homodimeric enzyme [PMID: 11955070].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD