Domain

Sorting nexin Vps5, BAR domain (IPR035803)

Short name: BAR_Vps5

Domain relationships

Description

Sorting nexins (SNXs) are Phox homology (PX) domain-containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNXs differ from each other in their lipid-binding specificity, subcellular localization and specific function in the endocytic pathway. A subset of SNXs also contain BAR domains [PMID: 22168438]. The PX-BAR structural unit determines the specific membrane targeting of SNXs [PMID: 12181349].

Vsp5p is the yeast counterpart of human SNX1 and is part of the retromer complex, which functions in the endosome-to-Golgi retrieval of vacuolar protein sorting receptor Vps10p, as well as other later-Golgi proteins [PMID: 9700157, PMID: 9285823, PMID: 12181349].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD