Pathways & interactions
Sorting nexin Vps5, BAR domain (IPR035803)
Short name: BAR_Vps5
Overlapping homologous superfamilies
- AH/BAR domain superfamily (IPR027267)
- Sorting nexin Vps5-like, C-terminal (IPR015404)
- Sorting nexin Vps5, BAR domain (IPR035803)
Sorting nexins (SNXs) are Phox homology (PX) domain-containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNXs differ from each other in their lipid-binding specificity, subcellular localization and specific function in the endocytic pathway. A subset of SNXs also contain BAR domains [PMID: 22168438]. The PX-BAR structural unit determines the specific membrane targeting of SNXs [PMID: 12181349].
Vsp5 is the yeast counterpart of human SNX1 and is part of the retromer complex, which functions in the endosome-to-Golgi retrieval of vacuolar protein sorting receptor Vps10, as well as other later-Golgi proteins [PMID: 9700157, PMID: 9285823, PMID: 12181349].
- cd07627 (BAR_Vps5p)