Tepsin, ENTH/VHS domain (IPR035802)

Short name: ENTH/VHS_tepsin

Overlapping homologous superfamilies

Domain relationships

  • ENTH domain (IPR013809)
    • Tepsin, ENTH/VHS domain (IPR035802)


Tepsin (also known as the product of the ENTHD2 or AP4AT gene) is an AP-4 accessory protein. It binds to the beta4-ear domain of AP-4, and is recruited to the trans-Golgi network (TGN) in manner dependent on this interaction [PMID: 26542808]. This is the ENTH/VHS domain in tepsin and in A. thaliana protein At3g16270 [PMID: 15014234].

Unlike the other members of the ENTH/ANTH/VHS superfamily, the tepsin ENTH domain lacks helix0, helix8, and a lipid binding pocket. Loss of helix0 precludes formation of a lipid binding pocket and explains why tepsin ENTH domain cannot interact directly with phosphoinositide head groups [PMID: 28691777].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.