Protein-ADP-ribose hydrolase, macro domain (IPR035801)

Short name: Macro_1

Overlapping homologous superfamilies


Domain relationships

  • Macro domain (IPR002589)
    • Protein-ADP-ribose hydrolase, macro domain (IPR035801)


Macrodomains are evolutionary widespread ADP-ribose-binding domains [PMID: 19273270] that have the potential to reverse sirtuin reactions either by hydrolysis of ADP-ribosylated protein substrates [PMID: 23711178], or by deacylating O-acyl-ADP-ribose [PMID: 21257746]. This macrodomain is present in proteins that act as protein-ADP-ribose hydrolases. It is found primarily in pathogenic microorganisms where it is genetically linked to a distinct class of sirtuins that function as protein ADP-ribosyl transferases [PMID: 26166706].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.