Domain

GDAP2, macro domain (IPR035793)

Short name: Macro_GDAP2

Overlapping homologous superfamilies

None.

Domain relationships

Description

This macro domain is found in proteins similar to human GDAP2, the ganglioside induced differentiation associated protein 2, whose gene is expressed at a higher level in differentiated Neuro2a cells compared with non-differentiated cells [PMID: 10217254]. GDAP2 contains an N-terminal macro domain and a C-terminal Sec14p-like lipid binding domain. It is specifically expressed in brain and testis.

The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ADP-ribose as a ligand. Previously identified as displaying an Appr-1"-p (ADP-ribose-1"-monophosphate) processing activity, the macro domain may play roles in distinct ADP-ribose pathways, such as the ADP-ribosylation of proteins, an important post-translational modification which occurs in DNA repair, transcription, chromatin biology, and long-term memory formation, among other processes [PMID: 15902274].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD