Domain

Heterogeneous nuclear ribonucleoprotein U, SPRY domain (IPR035778)

Short name: SPRY_hnRNP_U

Overlapping homologous superfamilies

Domain relationships

  • B30.2/SPRY domain (IPR001870)
    • Heterogeneous nuclear ribonucleoprotein U, SPRY domain (IPR035778)

Description

This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of heterogeneous nuclear ribonucleoprotein U (hnRNP U) and hnRNP U-like proteins 1 and 2.

hnRNP U contains three conserved domains: a SAF-Box that binds to AT-rich chromosomal region known as a scaffold- or matrix-attachment region (S/MAR), SPRY (Spla and Ryanodine receptor) domain of unknown function, and RGG (arginine-glycine-glycine) RNA-binding domain. hnRNP U is involved in transcription [PMID: 23811339], alternative splicing [PMID: 23396972] and inactivation one of the two female X chromosomes [PMID: 20833368]. hnRNP U-like proteins 1 and 2 play key roles in cellular responses to double-strand breaks (DSBs) [PMID: 22365830, PMID: 23577092].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD