CD2-associated protein, third SH3 domain (IPR035777)

Short name: CD2AP_SH3_3

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • CD2-associated protein, third SH3 domain (IPR035777)


CD2AP is a multifunctional adaptor protein involved in membrane trafficking, dynamic actin remodelling and endocytosis [PMID: 26296892, PMID: 27765817]. CD2AP contains three SH3 domains, a proline-rich region, and a C-terminal coiled-coil domain. Different biological processes regulated by CD2AP require specific binding partners [PMID: 26296892].

This entry represents the third SH3 domain (SH3C) of CD2AP. SH3C has been shown to bind ubiquitin [PMID: 19359362].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.