Ryanodine receptor, SPRY domain 2 (IPR035764)

Short name: SPRY2_RyR

Overlapping homologous superfamilies


Domain relationships

  • SPRY domain (IPR003877)
    • Ryanodine receptor, SPRY domain 2 (IPR035764)


This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1 [PMID: 19076161, PMID: 21239886].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.