NADPH oxidase organiser 1, second SH3 domain (IPR035758)

Short name: NoxO1_SH3_2

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • NADPH oxidase organiser 1, second SH3 domain (IPR035758)


Nox Organizing protein 1 (NoxO1) is a critical regulator of enzyme kinetics of the nonphagocytic NADPH oxidase Nox1, which catalyzes the transfer of electrons from NADPH to molecular oxygen to form superoxide [PMID: 20001746]. NoxO1 is involved in targeting activator subunits (such as NoxA1) to Nox1. It is co-localized with Nox1 in the membranes of resting cells and directs the subcellular localization of Nox1 [PMID: 14617635]. NoxO1 contains an N-terminal Phox homology (PX) domain, tandem SH3 domains (N-SH3 and C-SH3), and a C-terminal proline-rich region (PRR).

This entry represents the second SH3 domain (or C-SH3) of NoxO1. The tandem SH3 domains of NoxO1 interact with the PRR of p22phox, which also complexes with Nox1 [PMID: 17126813].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.