Dynein heavy chain, ATP-binding dynein motor region D5 (IPR035706)

Short name: DHC_D5

Overlapping homologous superfamilies


Domain relationships



Dyneins are multiprotein complexes that move cargo along microtubules in the minus end direction. The largest component of the dynein complex is the heavy chain. Its C terminus forms the motor unit [PMID: 27062277].

The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This domain is the D5 ATP-binding region of the motor, but has lost its P-loop [PMID: 11250194].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.