Domain

SNX18, PX domain (IPR035703)

Short name: SNX18_PX

Overlapping homologous superfamilies

Domain relationships

Description

Sorting nexin-18 (SNX18) is localized to peripheral endosomal structures, and acts in a trafficking pathway that is clathrin-independent but relies on AP-1 and PACS1 [PMID: 18411244]. It binds FIP5 and is required for apical lumen formation [PMID: 21969467]. It may also play a role in axonal elongation [PMID: 21339182]. SNXs are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system [PMID: 18411244, PMID: 21048941]. SNX18 also contains BAR and SH3 domains.

The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions. Sorting nexins (SNXs) make up the largest group among PX domain containing proteins. They are involved in regulating membrane traffic and protein sorting in the endosomal system. The PX domain of SNXs binds PIs and targets the protein to PI-enriched membranes [PMID: 16782399].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD