Family

Caspase-2 (IPR035702)

Short name: Caspase_2

Overlapping homologous superfamilies

Family relationships

Description

This entry includes the cysteine endopeptidase caspase-2 (MEROPS identifier C14.006), one of the caspases in the cascade that leads to apoptosis. Many cytoplasmic proteins have been identified as substrates for caspase-2 [PMID: 27006500]. One of these proteins is Bid, which is inactivated by caspase-2 and the serine endopeptidase granzyme B, and which ultimately leads to the release of cytochrome C from the mitochondrion and activation of the executor caspases by caspase-9 [PMID: 11832478].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER