Magnesium-dependent phosphatase-1, eukaryotic-type (IPR035679)

Short name: MDP-1_euk

Overlapping homologous superfamilies

Family relationships


This family includes eukaryotic magnesium-dependent phosphatase-1 (MDP-1) which is most likely a phosphotyrosine phosphatase catalyzing the dephosphorylation of tyrosine-phosphorylated proteins [PMID: 10889041, PMID: 11601995], and some bacterial sequences annotated as FkbH-like proteins. This family belongs to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.