ERdj5, first thioredoxin domain (IPR035673)

Short name: ERdj5_TRX_N

Overlapping homologous superfamilies

Domain relationships


ERdj5, also known as Dnajc10 (DnaJ homologue subfamily C member 10), JPDI or macrothioredoxin, is a protein containing an N-terminal DnaJ domain and four redox active TRX domains [PMID: 14587667]. This entry comprises the first TRX domain of ERdj5 located after the DnaJ domain at the N-terminal half of the protein. ERdj5 is a ubiquitous protein localized in the endoplasmic reticulum (ER) and is abundant in secretory cells. It's transcription is induced during ER stress [PMID: 12411443]. It interacts with BiP through its DnaJ domain in an ATP-dependent manner. BiP, an ER-resident member of the Hsp70 chaperone family, functions in ER-associated degradation and protein translocation [PMID: 12446677].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.