Elongation factor 4, domain IV (IPR035654)

Short name: LepA_IV

Overlapping homologous superfamilies


Domain relationships


Elongation factor 4, also known as ribosomal back-translocase LepA, is required for accurate and efficient protein synthesis under certain stress conditions. Its function is not clear. However, it may act as a fidelity factor of the translation reaction, by catalysing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly [PMID: 17110332, PMID: 20045415]. Elongation factor 4 binds to ribosomes in a GTP-dependent manner. The eukaryotic homologue is known as GUF1 and promotes protein synthesis in chloroplasts and mitochondria [PMID: 18442968].

EF4 has six domains, of which four (I, II, III, and V) are homologous to corresponding domains in EF-G [PMID: 18362332, PMID: 25104389, PMID: 28320876]. This entry represents domain IV of EF4, homologous to domain V of EF-G.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.