Ephexin-1, SH3 domain (IPR035635)

Short name: Ephexin-1_SH3

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • Ephexin-1, SH3 domain (IPR035635)


Ephexin-1 is a RhoGEF (Rho-type guanine nucleotide exchange factor) that activates RhoA, Tac1, and Cdc42 by exchanging bound GDP for free GTP [PMID: 19249276]. It is expressed mainly in the brain in a region associated with movement control. It regulates the stability of postsynaptic acetylcholine receptor (AChR) clusters and thus plays a critical role in the maturation and neurotransmission of neuromuscular junctions [PMID: 20152127]. Ephexin-1 directly interacts with the ephrin receptor EphA4 and their coexpression enhances the ability of ephexin-1 to activate RhoA [PMID: 11336673]. It is required for normal axon growth and EphA-induced growth cone collapse [PMID: 15848799].

Ephexin-1 contains RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH) and SH3 domains. This entry represents the SH3 domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.