UBASH3B, SH3 domain (IPR035632)

Short name: UBASH3B_SH3

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • UBASH3B, SH3 domain (IPR035632)


This entry represents the SH3 domain of UBASH3B.

UBASH3B (also known as STS-1 or TULA-2), belongs to the TULA family, is an active phosphatase that is expressed ubiquitously [PMID: 20670933]. The phosphatase activity of UBASH3B is essential for its roles in the suppression of TCR signaling [PMID: 17679096] and the regulation of EGFR [PMID: 15159412]. It also interacts with Syk and functions as a negative regulator of platelet glycoprotein VI signaling in platelets [PMID: 20585042].

The TULA family includes two members termed p70/STS-1/TULA-2 and UBASH3A/STS-2/TULA/Cbl-InteractingProtein 4 (CLIP4). TULA proteins contain an N-terminal UBA domain, a central SH3 domain, and a C-terminal histidine phosphatase domain. They bind c-Cbl (a multidomain adaptor and an E3 ubiquitinligase) through the SH3 domain [PMID: 15159412] and to ubiquitin via UBA [PMID: 18344182].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.