Domain

DUS-like, FMN-binding domain (IPR035587)

Short name: DUS-like_FMN-bd

Domain relationships

None.

Description

This entry represents a dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archaea. Most dihydrouridines are found in the D loop of tRNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap [PMID: 12003496, PMID: 11983710]. 1VHN, a putative flavin oxidoreductase, has high sequence similarity to DUS. The enzymatic mechanism of 1VHN is not known at the present [PMID: 15103641].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD