Sorting nexin-18, SH3 domain (IPR035557)

Short name: SNX18_SH3

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • Sorting nexin-18, SH3 domain (IPR035557)


Sorting nexin-18 (SNX18) is localized to peripheral endosomal structures, and acts in a trafficking pathway that is clathrin-independent but relies on AP-1 and PACS1 [PMID: 18411244]. It binds FIP5 and is required for apical lumen formation [PMID: 21969467]. It may also play a role in axonal elongation [PMID: 21339182]. SNXs are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system [PMID: 18411244, PMID: 21048941]. SNX18 also contains BAR and SH3 domains.

This entry represent the SH3 domain of SNX18.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.