DBS, PH domain (IPR035534)

Short name: DBS_PH

Domain relationships


This entry represents the PH domain of guanine nucleotide exchange factor DBS. The DBS PH domain participates in binding to both the Cdc42 and RhoA GTPases [PMID: 12637522]. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner [PMID: 22728242].

DBS, also called MCF2L or OST, functions as a Rho GTPase guanine nucleotide exchange factor (RhoGEF), facilitating the exchange of GDP and GTP. It was originally isolated from a cDNA screen for sequences that cause malignant growth. It plays roles in regulating clathrin-mediated endocytosis and cell migration through its activation of Rac1 and Cdc42 [PMID: 17562712, PMID: 19366686]. Depending on cell type, DBS can also activate RhoA and RhoG [PMID: 17000758, PMID: 14991610]. DBS contains a Sec14-like domain [PMID: 15531584], spectrin-like repeats, a RhoGEF or Dbl homology (DH) domain, a Pleckstrin homology (PH) domain [PMID: 15274927], and an SH3 domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.