DBS, PH domain (IPR035534)

Short name: DBS_PH

Overlapping homologous superfamilies

Domain relationships


This entry represents the PH domain of guanine nucleotide exchange factor DBS. The DBS PH domain participates in binding to both the Cdc42 and RhoA GTPases [PMID: 12637522]. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner [PMID: 22728242].

DBS, also called MCF2L or OST, functions as a Rho GTPase guanine nucleotide exchange factor (RhoGEF), facilitating the exchange of GDP and GTP. It was originally isolated from a cDNA screen for sequences that cause malignant growth. It plays roles in regulating clathrin-mediated endocytosis and cell migration through its activation of Rac1 and Cdc42 [PMID: 17562712, PMID: 19366686]. Depending on cell type, DBS can also activate RhoA and RhoG [PMID: 17000758, PMID: 14991610]. DBS contains a Sec14-like domain [PMID: 15531584], spectrin-like repeats, a RhoGEF or Dbl homology (DH) domain, a Pleckstrin homology (PH) domain [PMID: 15274927], and an SH3 domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.