MUM1-like, PWWP domain (IPR035504)

Short name: MUM1-like_PWWP

Overlapping homologous superfamilies


Domain relationships



PWWP domain-containing protein EXPAND1/MUM1 is a nucleosome-binding protein that contributes to the maintenance of chromatin state. Through its interaction with 53BP1, it serves as an accessory factor in the DNA damage response pathway to promote chromatin change in response to DNA damage [PMID: 20347427]. MUM1 promotes cell survival following DNA damage, suggesting that it may facilitate DNA repair by regulating the organization of chromatin structure [PMID: 21327088].

This entry represents the PWWP domain. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding proteins, that function as transcription factors regulating a variety of developmental processes [PMID: 10802047].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.