BR140-related, PWWD domain (IPR035502)

Short name: BR140-rel_PWWD

Overlapping homologous superfamilies


Domain relationships

  • PWWP domain (IPR000313)
    • BR140-related, PWWD domain (IPR035502)


The PWWP domain is found in the BR140 family, which includes peregrine (also known as protein BR140 or Brpf1) and BR140-like proteins 1 and 2 (Bromodomain and PHD finger-containing proteins 2 and 3). BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. Brpf1 is part of the MOZ/MORF complex which has a histone H3 acetyltransferase activity [PMID: 6387653, PMID: 27939640]. The PWWP domain of Brpf1 has been shown to bind H3K36me3 [PMID: 20400950].

The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding proteins, that function as transcription factors regulating a variety of developmental processes [PMID: 10802047].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.