NP60, PWWP domain (IPR035501)

Short name: NP60_PWWP

Overlapping homologous superfamilies


Domain relationships

  • PWWP domain (IPR000313)
    • NP60, PWWP domain (IPR035501)


The PWWP domain is an essential part of the cytokine-like nuclear factor N-PAC protein, also known as NP60 or GLYR1, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha [PMID: 16352664]. NPAC/GLYR1 is a KDM1B demethylase cofactor that stimulates H3K4me1 and H3K4me2 demethylation [PMID: 23260659]. In addition to the PWWP domain, NP60 also contains an AT-hook and a C-terminal NAD-binding domain alpha [PMID: 16352664].

The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding proteins, that function as transcription factors regulating a variety of developmental processes [PMID: 10802047].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.