Phosphoglucose isomerase, SIS domain 1 (IPR035476)

Short name: SIS_PGI_1

Overlapping homologous superfamilies


Domain relationships



Phosphoglucose isomerase (PGI) is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate [PMID: 6115414]. As an extracellular protein, PGI also has functions equivalent to neuroleukin (NLK), autocrine motility factor (AMF), and maturation factor (MF) [PMID: 10318897, PMID: 10770936]. Evidence suggests that PGI, NLK, AMF, and MF are closely related or identical. NLK is a neurotrophic growth factor that promotes regeneration and survival of neurons. The dimeric form of NLK has isomerase function, whereas its monomeric form carries out neurotrophic activity. AMF is a cytokine that stimulates cell migration and metastasis. MF mediates the differentiation of human myeloid leukemic HL-60 cells to terminal monocytic cells.

PGI is comprised of two domains; each domain is an alpha-beta-alpha sandwich [PMID: 11371164], which correspond to a SIS (Sugar ISomerase) domain fold.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.