RpiR-like, SIS domain (IPR035472)

Short name: RpiR-like_SIS

Overlapping homologous superfamilies


Domain relationships


RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, RpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate [PMID: 8576032].

This domain is also found in other members of the RpiR family of transcriptional regulators, such as MurR [PMID: 18723630] and in uncharacterised proteins of the UPF0309 family.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.