Family

GmhA/DiaA (IPR035461)

Short name: GmhA/DiaA

Overlapping homologous superfamilies

None.

Family relationships

Description

Phosphoheptose isomerase (GmhA, LpcA) catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of Gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh) [PMID: 8655517].

GmhA shows high similarity to Escherichia coli DnaA initiator-associating protein A (DiaA) [PMID: 26612680], which is required for the timely initiation of chromosomal replication [PMID: 15326179].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD