FCHSD, SH3 domain 1 (IPR035460)

Short name: FCHSD_SH3_1

Overlapping homologous superfamilies

Domain relationships

  • SH3 domain (IPR001452)
    • FCHSD, SH3 domain 1 (IPR035460)


This entry represents the first SH3 domain found in the F-BAR and double SH3 domains proteins, including FCHSD1 and FCHSD2. These proteins have a common domain structure consisting of an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), two SH3, and C-terminal proline-rich domains [PMID: 15067381]. FCHSD1 and FCHSD2 are expressed in cochlear sensory hair cells. FCHSD2 interacts with WASP and N-WASP, and stimulates F-actin assembly in vitro. FCHSD1 does not bind to WASP, but binds via its F-BAR domain to the SH3 domain of Sorting Nexin 9, a BAR protein that has been shown to promote WASP-Arp2/3-dependent F-actin polymerization [PMID: 23437151]. FCHSD2 has been implicated in receptor endocytosis and transport [PMID: 28199211]. The insect protein nervous wreck, which acts as a regulator of synaptic growth signaling [PMID: 18701694], also contains this domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.