Zinc finger FYVE domain containing protein, SARA/endofin (IPR035438)

Short name: SARA/endofin

Overlapping homologous superfamilies


Family relationships


This group represents zinc finger FYVE domain-containing proteins SARA and endofin.

SARA (also known as zinc finger FYVE domain-containing protein 9) is a component of the TGFbeta pathway that functions to recruit Smad2 to the TGFbeta receptor [PMID: 9865696]. Endofin (zinc finger FYVE domain-containing protein 16) facilitates TGF-beta signaling by bringing Smad4 to the proximity of the receptor complex [PMID: 17272273]. Both are involved in regulating membrane trafficking in the endosomal pathway [PMID: 12432064, PMID: 11546807].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.