Homologous Superfamily

Tim10-like domain superfamily (IPR035427)

Short name: Tim10-like_dom_sf

Overlapping entries

Description

This domain superfamily is found in mitochondrial import inner membrane translocase subunits Tim8, Tim9, Tim10 and Tim13, which are located in the mitochondrial intermembrane space.

The Tim8-Tim13 complex has a complex architecture, similar to the Tim9-Tim10 complex, composed of a hexametric architecture with long helices which look like tentacles extend from a central loop [PMID: 18706423]. In each subunit of the Tim9-Tim10 complex, a signature "twin CX3C" motif forms two intramolecular disulfides [PMID: 16387659].

Tim9 plays an important functional role that includes facilitating the initial steps in translocating precursor substrates into the intermembrane space [PMID: 19037098].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY
GENE3D