Homologous Superfamily

Peptidase M29, N-terminal (IPR035097)

Short name: M29_N-terminal

Overlapping entries

Description

This superfamily represents a domain found in a group of metallopeptidases that belong to MEROPS peptidase family M29 (aminopeptidase T family, clan M-), and that includes AmpS and AmpT.

Staphylococcus aureus aminopeptidase S (AmpS) has been named for its predicted, but experimentally untested, aminopeptidase activity. The enzyme is homologous to biochemically characterized aminopeptidases. It is a dimeric protein with a very unusual, elongated shape and a large internal cavity [PMID: 15932875]. Aminopeptidase T (AmpT) from Thermus thermophilus is an homologue of AmpS. AmpT, like AmpS, can be divided into an N-terminal domain and a C-terminal domain, with a flexible hinge between them [PMID: 16242715]. This entry represent the N-terminal domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D