Homologous Superfamily

Toxin-antitoxin system, RelE/ParE toxin domain superfamily (IPR035093)

Short name: RelE/ParE_toxin_dom_sf

Overlapping entries


The RelE/ParE family encompasses several toxin components of toxin-antitoxin modules. RelE is a sequence-specific, ribosome-dependent mRNA endoribonuclease which inhibits translation during amino acid starvation [PMID: 15718296]. ParE is involved in plasmid partition. ParE acts by inhibiting DNA gyrase, converting supercoiled plasmid DNA into a singly cleaved linear form in an ATP-dependent fashion [PMID: 8133518, PMID: 12010492].

Toxin-antitoxin (TA) systems form a prokaryotic proteins ubiquitous class with functional roles in plasmid inheritance/environmental stress response/cell development. ParDE family TA systems are broadly conserved on plasmids/bacterial chromosomes. They have been well characterized as genetic elements that promote stable plasmid inheritance.

The ParD-ParE complex TA system structure forms an alpha2-beta2 heterotetramer. The ParE toxin is a basic 96 amino acid protein, its structure contains two N-terminal alpha-helices. ParE is similar to the E. coli YoeB (YefM-YoeB)/RelE (RelB-RelE) endoribonucleases [PMID: 2846751].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.