Homologous Superfamily

EspA/CesA-like (IPR035074)

Short name: EspA/CesA-like

Overlapping entries


EspA, together with EspB, EspD and Tir are exported by a type III secretion system. These proteins are essential for attaching and effacing lesion formation. EspA is a structural protein and a major component of a large, transiently expressed, filamentous surface organelle which forms a direct link between the bacterium and the host cell [PMID: 9545230, PMID: 10760148].

CesA acts as a chaperone of secreted protein EspA, trapping EspA in a monomeric state and inhibiting its polymerization. Both adopt similar substructures in the heterodimer. CesA adopts an extended all-helical topology with an overall hairpin shape. EspA contains two long alpha-helices, which are involved in extensive coiled-coil interactions with CesA [PMID: 15619638].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.