Serine/threonine-protein kinase PAK2/3 (IPR035065)

Short name: PAK2/3

Overlapping homologous superfamilies

Family relationships



PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis [PMID: 10200518]. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response [PMID: 11345898]. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1 [PMID: 18411304]. PAK2 belongs to the group I PAKs.

PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis [PMID: 18507705, PMID: 21949127]. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation [PMID: 15581714, PMID: 18523455]. PAK3 belongs to the group I PAKs.

Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac [PMID: 11950587].

GO terms

Biological Process

GO:0042981 regulation of apoptotic process

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.