p21-activated kinase 2, catalytic domain (IPR035064)
Short name: STK_PAK2
Overlapping homologous superfamilies
- Protein kinase-like domain superfamily (IPR011009)
- Protein kinase domain (IPR000719)
- p21-activated kinase 2, catalytic domain (IPR035064)
PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis [PMID: 10200518]. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response [PMID: 11345898]. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1 [PMID: 18411304]. PAK2 belongs to the group I PAKs.
Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac [PMID: 11950587].
This entry corresponds to the PAK2 C-terminal catalytic domain.
- cd06655 (STKc_PAK2)