p21-activated kinase 3, catalytic domain (IPR035063)

Short name: STK_PAK3

Overlapping homologous superfamilies

Domain relationships


This entry represents the catalytic domain of serine/threonine kinase p21-activated kinase (PAK) 3.

PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis [PMID: 18507705, PMID: 21949127]. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation [PMID: 15581714, PMID: 18523455]. PAK3 belongs to the group I PAKs.

Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac [PMID: 11950587].

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.