p21-activated kinase 3, catalytic domain (IPR035063)
Short name: STK_PAK3
Overlapping homologous superfamilies
- Protein kinase-like domain superfamily (IPR011009)
- Protein kinase domain (IPR000719)
- p21-activated kinase 3, catalytic domain (IPR035063)
This entry represents the catalytic domain of serine/threonine kinase p21-activated kinase (PAK) 3.
PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis [PMID: 18507705, PMID: 21949127]. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation [PMID: 15581714, PMID: 18523455]. PAK3 belongs to the group I PAKs.
Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac [PMID: 11950587].
- cd06656 (STKc_PAK3)