Serine/threonine kinase 25, catalytic domain (IPR035060)

Short name: STK_STK25

Overlapping homologous superfamilies

Domain relationships


STK25 is also called Ste20/oxidant stress response kinase 1 (SOK1) or yeast Sps1/Ste20-related kinase 1 (YSK1). It is localized in the Golgi apparatus through its interaction with the Golgi matrix protein GM130 [PMID: 15037601]. It may be involved in the regulation of cell migration and polarization. STK25 binds and phosphorylates CCM3 (cerebral cavernous malformation 3), also called PCD10 (programmed cell death 10), and may play a role in apoptosis [PMID: 17657516]. Human STK25 is a candidate gene responsible for pseudopseudohypoparathyroidism (PPHP), a disease that shares features with the Albright hereditary osteodystrophy (AHO) phenotype [PMID: 11543625].

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.