SH2B3, SH2 domain (IPR035059)

Short name: SH2B3_SH2

Overlapping homologous superfamilies

Domain relationships

  • SH2 domain (IPR000980)
    • SH2B3, SH2 domain (IPR035059)


This entry represents the SH2 domain of SH2B3.

SH2B adapter protein 3 (SH2B3) belongs to the SH2B family of adapter proteins [PMID: 11498022]. It is involved in the homeostasis of hematopoietic stem cells and lymphoid progenitors, and plays a tumour suppressor role in the acute lymphoblastic leukemia [PMID: 11805142, PMID: 23908464, PMID: 24092923]. SH2B3 (Lnk) may also influence inflammatory immune responses in peripheral lymphoid tissues [PMID: 25024389]. A link has been established between polymorphism in this adaptor protein and autoimmune diseases, including type 1 diabetes and celiac disease [PMID: 19073967, PMID: 18311140, PMID: 19648290].

SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 [PMID: 17140804]. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor [PMID: 11498022].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.