Domain

RPK118-like, kinase domain (IPR035053)

Short name: STK_RPK118-like

Overlapping homologous superfamilies

Domain relationships

Description

This entry represents the catalytic domain of the Serine/Threonine Kinase, RPK118 (also known as ribosomal protein S6 kinase delta-1) and similar proteins. RPK118 contains an N-terminal Phox homology (PX) domain, a Microtubule Interacting and Trafficking (MIT) domain, and a kinase domain containing a long uncharacterized insert. This domain is also present in human RPK60 (or ribosomal protein S6 kinase-like 1), which also contains a MIT domain, but lacks a PX domain.

RPK118 binds sphingosine kinase, a key enzyme in the synthesis of sphingosine 1-phosphate (SPP), a lipid messenger involved in many cellular events. RPK118 may be involved in transmitting SPP-mediated signaling [PMID: 12077123]. RPK118 also binds the antioxidant peroxiredoxin-3 (PRDX3). RPK118 may be involved in the transport of PRDX3 from the cytoplasm to its site of function in the mitochondria [PMID: 15750338].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD