Ribosomal protein S6 kinase delta-1 (IPR035051)

Short name: S6K-delta-1

Overlapping homologous superfamilies


Family relationships



Ribosomal protein S6 kinase delta-1, also known as RPK118, binds sphingosine kinase-1, a key enzyme in the synthesis of the lipid messenger sphingosine 1 phosphate (SPP). It may be involved in transmitting SPP-mediated signaling into the cell [PMID: 12077123]. RPK118 specifically binds to phosphatidylinositol 3-phosphate [PMID: 12077123]. RPK118 also binds peroxiredoxin-3 and may be involved in transporting peroxiredoxin-3 from the cytoplasm to its mitochondrial site of function via endosome trafficking [PMID: 15750338]. The C terminus of RPK118 consist of a domain with conserved Ser/Thr protein kinase residues, specially resembling human ribosome protein S6 kinase [PMID: 10552933].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.