Tripartite motif-containing protein 72 (IPR035038)

Short name: TRIM72

Overlapping homologous superfamilies


Family relationships



TRIM72, also known as MG53, is a cardiac and skeletal muscle-specific TRIM protein. It is involved in cardiac and skeletal muscle membrane repair [PMID: 20466981]. TRIM72 initiates the assembly of cell membrane repair machinery at sarcolemmal membrane injury sites in response to entry of the extracellular oxidative environment [PMID: 19043407]. As an E3 ligase, it negatively regulates skeletal myogenesis and insulin signalling by targeting insulin receptor substrate 1 (IRS-1) [PMID: 23965929].

Tripartite Motif (TRIM) family members share a common domain architecture characterised by the presence of a modular N-terminal RBCC motif, also called the TRIM, which consists of a RING domain, followed by one or two B-box domains and a long coiled coil (CC) region. The RBCC motif is followed by C-terminal functional domains that are often used to categorise family members into subgroups [PMID: 18836477].TRIM72 C terminus consists of the distinct N-terminal PRY subdomain followed by the SPRY subdomain.

GO terms

Biological Process

GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0001778 plasma membrane repair

Molecular Function

GO:0061630 ubiquitin protein ligase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.