Growth factor receptor-bound protein 14 (IPR035035)

Short name: Grb14

Overlapping homologous superfamilies


Family relationships

  • GRB/APBB1IP (IPR039664)
    • Growth factor receptor-bound protein 14 (IPR035035)


The Grb7 (growth factor receptor-bound 7) family includes Grb7, Grb10, and Grb14. These are adapter proteins mediating signal transduction from multiple cell surface receptors to diverse downstream pathways. They are composed of an N-terminal proline-rich domain, a Ras Associating-like (RA) domain, a Pleckstrin Homology (PH) domain, a PIR (phosphorylated insulin receptor interacting region) domain (also known as the family-specific BPS region), and a C-terminal SH2 domain [PMID: 19648926].

Grb14 binds to various receptor tyrosine kinases (RTKs) under ligand induction. This interaction involves the SH2 and PIR domains [PMID: 14977573].

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0005070 SH3/SH2 adaptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.