Family

Growth factor receptor-bound protein 7 (IPR035032)

Short name: Grb7

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Grb7 (growth factor receptor bound protein 7) is an adapter protein mediating signal transduction from multiple cell surface receptors to diverse downstream pathways [PMID: 17318180, PMID: 1827306, PMID: 24089360]. It contains a Ras-associating (RA) domain, a pleckstrin-homology (PH) domain, a family-specific BPS (between PH and SH2) region and a C-terminal SH2 domain [PMID: 19648926, PMID: 14766359]. It can bind to the epidermal growth factor receptor (EGFR, erbB1) via the SH2 domain [PMID: 12975581].

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

GO:0005070 SH3/SH2 adaptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER