E3 ubiquitin-protein ligase TRIM9 (IPR035029)

Short name: TRIM9

Overlapping homologous superfamilies


Family relationships



Tripartite motif containing 9 (TRIM9) is highly expressed in the cerebral cortex and hippocampus, and plays an important role in the regulation of neuronal functions. Its expression is reduced in memory loss neuropathologies, including Parkinson's disease and dementia with Lewy bodies [PMID: 20085810]. TRIM9 functions as an E3 ubiquitin ligase collaborating with an E2 ubiquitin conjugating enzyme UbcH5b [PMID: 20085810]. It is also involved in regulating neuronal branching by acting as a catalytic link between Netrin-1 and the exocytic SNARE machinery. TRIM9 interaction with SNAP25 inhibits SNARE complex formation. After Netrin-1 stimulation TRIM9 releases SNAP25, and this release promotes Netrin-1-dependent SNARE-mediated vesicle fusion and axon branching [PMID: 24778312].

GO terms

Biological Process

GO:0035544 negative regulation of SNARE complex assembly

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.