Domain

cGMP-dependent protein kinase, catalytic domain (IPR035014)

Short name: STKc_cGK

Domain relationships

Description

Mammals have two cGMP-dependent protein kinase (cGK) isoforms from different genes, cGKI and cGKII. cGKI exists as two splice variants, cGKI-alpha and cGKI-beta. cGK consists of an N-terminal regulatory domain containing a dimerization and an autoinhibitory pseudosubstrate region, two cGMP-binding domains, and a C-terminal catalytic domain. Binding of cGMP to both binding sites releases the inhibition of the catalytic centre by the pseudosubstrate region, allowing autophosphorylation and activation of the kinase [PMID: 15545263, PMID: 23709024].

cGKI is a soluble protein expressed in all smooth muscles, platelets, cerebellum, and kidney. It is also expressed at lower concentrations in other tissues. cGKII is a membrane-bound protein that is most abundantly expressed in the intestine. It is also present in the brain nuclei, adrenal cortex, kidney, lung, and prostate. cGKI is involved in the regulation of smooth muscle tone, smooth cell proliferation, and platelet activation. cGKII plays a role in the regulation of secretion, such as renin secretion by the kidney and aldosterone secretion by the adrenal. It also regulates bone growth and the circadian rhythm [PMID: 15545263, PMID: 23709024, PMID: 15769624].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004692 cGMP-dependent protein kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD