Domain

UPF3B, RNA recognition motif-like domain (IPR034979)

Short name: UPF3B_RRM-like

Overlapping homologous superfamilies

Domain relationships

Description

This entry represents the RNA recognition motif (RRM)-like domain in Upf3B, a human orthologue of yeast Upf3p and Caenorhabditis elegans SMG-4 [PMID: 11113196]. It derives from X-linked gene UPF3B and is required for nonsense-mediated mRNA decay (NMD) in human [PMID: 11546873]. Upf3B is a nucleocytoplasmic shuttling protein that associates selectively with spliced beta-globin mRNA in vivo [PMID: 11163187]. Like other Upf3 proteins, Upf3B contains nuclear import and export signals, and a conserved domain with some similarity to an RNA recognition motif (RRM), indicating that it may be an RNA binding protein.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD