Family

Reelin (IPR034968)

Short name: Reelin

Overlapping homologous superfamilies

Family relationships

None.

Description

Reelin is an extracellular matrix serine protease that regulates neuronal migration during embryonic development and acts as a modulator of synaptic transmission in the adult brain [PMID: 20525064]. Reelin acts on its receptors, VLDLR and ApoER2, acting on cytoskeleton, controlling migration and subsequently positioning and stabilizing the cortical neurons [PMID: 10571240, PMID: 10380922, PMID: 19396394]. In the adult brain, reelin stabilizes the actin cytoskeleton by inducing cofilin phosphorylation. Decreased Reelin expression causes destabilization of neurons, which could have implications for brain disorders, such as epilepsy and schizophrenia [PMID: 20598379].

GO terms

Biological Process

GO:0007417 central nervous system development
GO:0001764 neuron migration

Molecular Function

GO:0070325 lipoprotein particle receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER