Regulator of G-protein signalling 13 (IPR034954)

Short name: RGS13

Overlapping homologous superfamilies

Family relationships



RGS13 is a member of R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs) [PMID: 16226429]. Signaling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).

RGS13 exhibits relatively restricted tissue expression in T and B lymphocytes, as well as mast cells (MCs). RGS13 acts together with RGS1 to regulate chemokine receptor signaling in germinal centre B lymphocytes [PMID: 12193720, PMID: 16565322]. In MCs, it inhibits G protein-coupled receptor signaling and suppresses IgE-antigen-induced MC degranulation and anaphylaxis [PMID: 18026105].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.