Regulator of G-protein signalling 4 (IPR034952)

Short name: RGS4

Overlapping homologous superfamilies

Family relationships



RGS4 is a member of R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) [PMID: 16226429]. Signalling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).

RGS4 is expressed widely in brain and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling [PMID: 18006065]. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia [PMID: 22284188, PMID: 17880927, PMID: 17071056]. RGS4 also is up-regulated in the failing human heart [PMID: 11428836]. RGS4 interacts with many binding partners outside of GPCR pathways, including PIP, calcium/CaM, PA and 14-3-3 [PMID: 15746448, PMID: 16839744].

GO terms

Biological Process

GO:0007186 G protein-coupled receptor signaling pathway

Molecular Function

GO:0005096 GTPase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.